The role of CD28 in the prognosis of young lung adenocarcinoma patients.

ABSTRACT:

Background

The prognosis of lung cancer was found to be associated with a series of biomarkers related to the tumor immune microenvironment (TIME), which can modulate the biological behaviors and consequent outcomes of lung cancer. Therefore, establishing a prognostic model based on the TIME for lung cancer patients, especially young patients with lung adenocarcinoma (LUAD), is urgently needed.

Methods

In all, 809 lung cancer patients from the TCGA database and 71 young patients with LUAD in our center were involved in this study. Univariate and multivariate analysis based on clinical characteristics and TIME-related expression patterns (as evaluated by IHC) were performed to estimate prognosis and were verified by prognostic nomograms.

Results

Both LUAD and lung canc

SUBMITTER: Sun D 

PROVIDER: S-EPMC7510131 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature