Micronized sacchachitin promotes satellite cell proliferation through TAK1-JNK-AP-1 signaling pathway predominantly by TLR2 activation.

ABSTRACT:

Background

Ganoderma sp., such as Ganoderma tsugae (GT), play an important role in traditional Chinese medicine. Ganoderma sp. contains several constituents, including Sacacchin, which has recently drawn attention because it can not only enhance the repair of muscle damage but also strengthen the muscle enforcement. Although Ganoderma sp. have a therapeutic effect for neuromuscular disorders, the underlying mechanism remains unclear. This study investigated the effect and underlying molecular mechanism of micronized sacchachitin (mSC) on satellite cells (SCs), which are known as the muscle stem cells.

Methods

The myogenic cells, included SCs (Pax7⁺) were isolated from tibialis anterior muscles of a healthy rat and were cultured in growth media with different mSC c

SUBMITTER: Wu MH 

PROVIDER: S-EPMC7510329 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature