Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.

ABSTRACT:

Background

Lead (Pb) is a highly toxic pollutant. Evidence suggests it is associated with cardiovascular disease (CVD)-related mortality.

Objectives

We present a rigorous approach for identifying concentration-response functions that relate adult Pb exposures to CVD mortality to inform a health impact model (HIM). We then use the model in a proof-of-concept example.

Methods

Building on previously conducted government literature reviews and a de novo supplemental literature review, we compiled and evaluated the available data on Pb and CVD mortality in humans. We applied a set of predefined selection criteria to identify studies that would be most useful in understanding the impact of Pb exposure on CVD mortality risk in adults. Once we identified the studies, w

SUBMITTER: Brown L 

PROVIDER: S-EPMC7510336 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature