Genetic variation in TCF7L2 rs7903146 correlating with peripheral arterial disease in long-standing type 2 diabetes.

ABSTRACT:

Aim

The aim of this study was to investigate the association between the transcription factor 7-like 2 gene (TCF7L2) rs7903146 polymorphism and peripheral arterial disease in type 2 diabetes.

Methods

In total, 1818 Korean type 2 diabetes patients were enrolled from January 2013 to December 2017. Subjects were categorized into two groups according to their duration of type 2 diabetes: long (⩾10 years, n = 771) and short (<10 years, n = 1047) durations. A multivariate logistic regression model was used for assuming an additive effect on peripheral arterial disease for the presence of a variant allele in TCF7L2 rs7903146.

Results

The frequency of the minor T-allele was 7.6% (n = 139), and this allele was significantly associated with a

SUBMITTER: Ku EJ 

PROVIDER: S-EPMC7510358 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature