Dataset Information

Peripheral arterial disease and type 2 diabetes: Older patients still exhibit a survival benefit from glucose control.

ABSTRACT:

Objective

To investigate a possible beneficial effect of strict glycaemic control on all-cause mortality in patients with peripheral arterial disease and type 2 diabetes mellitus.

Methods

A total of 367 mainly older peripheral arterial disease patients [age: 69 (62-78) years, 34% women, Fontaine stage I-II] were categorized according to glycaemic control, that is, (a) no type 2 diabetes mellitus, (b) strict glucose control (HbA1c < 53 mmol/mol) and (c) lenient glucose control (HbA1c ⩾ 53 mmol/mol) at inclusion and by mean HbA1c over the first study year. Mortality was analysed using Kaplan-Meier and Cox-regression analyses after 7 years.

Results

The combination of type 2 diabetes mellitus and peripheral arterial disease reduced survival from 78.8% to 68.9% in comparison to patients without type 2 diabetes mellitus (p = 0.023). Patients with strict glucose control (75%) were associated with increased survival in comparison to patients with lenient glucose control (58.9%) stratified by mean HbA1c (p = 0.042). Baseline cardiovascular risk factors were similar in those type 2 diabetes mellitus patients. In this peripheral arterial disease cohort HbA1c (hazard ratio: 1.3, 1.04-1.63), age (hazard ratio: 1.7, 1.3-2.3) and C-reactive protein (hazard ratio: 1.5, 1.2-2.0) remained independent associates for mortality adjusted for cardiovascular risk factors and diabetes duration.

Conclusion

Older patients with peripheral arterial disease and type 2 diabetes mellitus still benefit from strict glucose control in a cohort of patients with similar distribution of cardiovascular risk factors.

SUBMITTER: Hobaus C

PROVIDER: S-EPMC7510380 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature

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Publications

Peripheral arterial disease and type 2 diabetes: Older patients still exhibit a survival benefit from glucose control.

Höbaus Clemens C Herz Carsten Thilo CT Wrba Thomas T Koppensteiner Renate R Schernthaner Gerit-Holger GH

Diabetes & vascular disease research 20200301 2

<h4>Objective</h4>To investigate a possible beneficial effect of strict glycaemic control on all-cause mortality in patients with peripheral arterial disease and type 2 diabetes mellitus.<h4>Methods</h4>A total of 367 mainly older peripheral arterial disease patients [age: 69 (62-78) years, 34% women, Fontaine stage I-II] were categorized according to glycaemic control, that is, (a) no type 2 diabetes mellitus, (b) strict glucose control (HbA1c < 53 mmol/mol) and (c) lenient glucose control (HbA ...[more]

PMID: 32308023

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Dataset Information

Peripheral arterial disease and type 2 diabetes: Older patients still exhibit a survival benefit from glucose control.

Objective

Methods

Results

Conclusion

Publications

Peripheral arterial disease and type 2 diabetes: Older patients still exhibit a survival benefit from glucose control.

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