High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ_1-42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes.

ABSTRACT: Due to an aging population, neurodegenerative diseases such as Alzheimer's disease (AD) have become a major health issue. In the case of AD, Aβ_{1 - 42} peptides have been identified as one of the markers of the disease with the formation of senile plaques via their aggregation, and could play a role in memory impairment and other tragic syndromes associated with the disease. Many studies have shown that not only the morphology and structure of Aβ_{1 - 42} peptide assembly are playing an important role in the formation of amyloid plaques, but also the interactions between Aβ_{1 - 42} and the cellular membrane are crucial regarding the aggregation processes and toxicity of the amyloid peptides. Despite

SUBMITTER: Feuillie C 

PROVIDER: S-EPMC7510551 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature