Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopy.

ABSTRACT: Since its first description and development in the late 20th century, diffusion magnetic resonance imaging (dMRI) has proven useful in describing the microstructural details of biological tissues. Signal generated from the protons of water molecules undergoing Brownian motion produces contrast based on the varied diffusivity of tissue types. Images employing diffusion contrast were first used to describe the diffusion characteristics of tissues, later used to describe the fiber orientations of white matter through tractography, and most recently proposed as a functional contrast method capable of delineating neuronal firing in the active brain. Thanks to the molecular origins of its signal source, diffusion contrast is inherently useful at describing features of the microenvironment; howev

SUBMITTER: Flint JJ 

PROVIDER: S-EPMC7510773 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature