Real-time augmented reality for delineation of surgical margins during neurosurgery using autofluorescence lifetime contrast.

ABSTRACT: Current clinical brain imaging techniques used for surgical planning of tumor resection lack intraoperative and real-time feedback; hence surgeons ultimately rely on subjective evaluation to identify tumor areas and margins. We report a fluorescence lifetime imaging (FLIm) instrument (excitation: 355 nm; emission spectral bands: 390/40 nm, 470/28 nm, 542/50 nm and 629/53 nm) that integrates with surgical microscopes to provide real-time intraoperative augmentation of the surgical field of view with fluorescent derived parameters encoding diagnostic information. We show the functionality and safety features of this instrument during neurosurgical procedures in patients undergoing craniotomy for the resection of brain tumors and/or tissue with radiation damage. We demonstrate in three case s

SUBMITTER: Alfonso-Garcia A 

PROVIDER: S-EPMC7510838 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature