Chemical Characterization of a Legacy Aqueous Film-Forming Foam Sample and Developmental Toxicity in Zebrafish (Danio rerio).

ABSTRACT:

Background

Drinking water contamination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter training facilities. AFFF has historically contained high levels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health concerns. However, the composition and toxicity of legacy AFFF mixtures are unknown, presenting great uncertainties in risk assessment and affected communities.

Objectives

This study aimed to determine the fluorinated and nonfluorinated chemical composition of a legacy AFFF sample and its toxicity in zebrafish embryos.

Methods

A sample of legacy AFFF (3% application formulation, manufactured before 2001) was provided by the Massachusetts Department of E

SUBMITTER: Annunziato KM 

PROVIDER: S-EPMC7510953 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature