Gene expression of the immunoinflammatory and immunological status of obese dogs before and after weight loss.

ABSTRACT: Obesity is characterized by a low degree of chronic inflammation state that, along with metabolic modifications, promotes important changes in the animal's organism. Adipose tissue actively participates in inflammation and immunity, and several defense cells of the organism may, therefore, be involved in the diversity found between obese and ideal weight individuals. Studies regarding this subject have shown immune cell changes in humans and rats, however, the literature is scarce in relation to dogs. Thus, the present study aimed to evaluate the gene expression profile of immunoinflammatory response and the lymphoproliferation of obese dogs before and after weight loss. Eight female dogs, neutered, of different breeds, aged between 1 and 8 years (4.74±3.19), obese, with body condition sco

SUBMITTER: Vendramini THA 

PROVIDER: S-EPMC7510989 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature