Degradable Hydrogels for the Delivery of Immune-modulatory Proteins in the Wound Environment.

ABSTRACT: Chronic wounds represent a growing clinical problem for which limited treatment strategies exist. Defects in immune cell-mediated healing play an important role in chronic wound development, presenting an attractive clinical target in the treatment of chronic wounds. However, efforts to improve healing through the application of growth factors and cytokines have been limited by the rapid degradation and diffusion of these molecules in the wound environment. In this study we sought to overcome the challenge of rapid diffusion through the development of a hydrogel delivery system in which protein cargo can be released into the wound environment at a constant and tunable rate. This system was used to deliver the intercellular adhesion molecule-1 (ICAM-1) in order to target endogenous cells up

SUBMITTER: Johnson M 

PROVIDER: S-EPMC7511088 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature