Correlated chromosomal periodicities according to the growth rate and gene expression.

ABSTRACT: Linking genetic information to population fitness is crucial to understanding living organisms. Despite the abundant knowledge of the genetic contribution to growth, the overall patterns/features connecting genes, their expression, and growth remain unclear. To reveal the quantitative and direct connections, systematic growth assays of single-gene knockout Escherichia coli strains under both rich and poor nutritional conditions were performed; subsequently, the resultant growth rates were associated with the original expression levels of the knockout genes in the parental genome. Comparative analysis of growth and the transcriptome identified not only the nutritionally differentiated fitness cost genes but also a significant correlation between the growth rates of the single-gene knockout

SUBMITTER: Liu L 

PROVIDER: S-EPMC7511328 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature