Characterization of the intergenerational impact of in utero and postnatal oxycodone exposure.

ABSTRACT: Prescription opioid abuse during and after pregnancy is a rising public health concern. While earlier studies have documented that offspring exposed to opioids in utero have impaired neurodevelopment, a significant knowledge gap remains in comparing the overall development between offspring exposed in utero and postnatally. Adding a layer of complexity is the role of heredity in the overall development of these exposed offspring. To fill in these important knowledge gaps, the current study uses a preclinical rat model mimicking oxycodone (oxy) exposure in utero (IUO) and postnatally (PNO) to investigate comparative and intergenerational effects in the two different treatment groups. While significant phenotypic attributes were observed with the two treatments and across the two generations

SUBMITTER: Odegaard KE 

PROVIDER: S-EPMC7511347 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature