Ontology highlight
ABSTRACT:
SUBMITTER: Tseng HC
PROVIDER: S-EPMC7511348 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Nature communications 20200923 1
Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for treating multiple refractory blood cancers, but further advances are required for solid tumor CAR therapy. One challenge is identifying a safe and effective tumor antigen. Here, we devise a strategy for targeting hepatocellular carcinoma (HCC, one of the deadliest malignancies). We report that T and NK cells transduced with a CAR that recognizes the surface marker, CD147, also known as Basigin, can effectively ...[more]