Overlapping Peptides Elicit Distinct CD8⁺ T Cell Responses following Influenza A Virus Infection.

ABSTRACT: The presentation of pathogen-derived peptides on MHC class I molecules is essential for the initiation of adaptive CD8⁺ T cell immunity, which in turn is critical for effective control of many significant human infections. The identification of immunogenic pathogen-derived epitopes and a detailed understanding of how they are recognized by TCRs is essential for the design of effective T cell-based vaccines. In this study, we have characterized the T cell recognition and immune responses in mice to two naturally presented influenza A virus-derived peptides previously identified from virally infected cells via mass spectrometry. These neuraminidase-derived peptides, NA_181-190 (SGPDNGAVAV) and NA_181-191 (SGPDNGAVAVL), are completely overlapping with the except

SUBMITTER: Assmus LM 

PROVIDER: S-EPMC7511415 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature