Assessing the Impact of I_h Conductance on Cross-Frequency Coupling in Model Pyramidal Neurons.

ABSTRACT: Large cortical and hippocampal pyramidal neurons are elements of neuronal circuitry that have been implicated in cross-frequency coupling (CFC) during cognitive tasks. We investigate potential mechanisms for CFC within these neurons by examining the role that the hyperpolarization-activated mixed cation current (I_h) plays in modulating CFC characteristics in multicompartment neuronal models. We quantify CFC along the soma-apical dendrite axis and tuft of three models configured to have different spatial distributions of I_h conductance density: (1) exponential gradient along the soma-apical dendrite axis, (2) uniform distribution, and (3) no I_h conductance. We simulated two current injection scenarios: distal apical 4 Hz modulation and perisomatic 4 Hz modul

SUBMITTER: Felton MA 

PROVIDER: S-EPMC7511577 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature