How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression.

ABSTRACT: C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood levels change rapidly and pronouncedly in response to any tissue damaging event associated with an inflammatory response. The synthesis and secretion of CRP is stimulated by interleukin-6, an early pleiotropic cytokine released by macrophages, endothelial, and other cells that are activated when localized normal tissue structures are compromised by trauma or disease. Serum CRP levels can change rapidly and robustly from 10-100-fold within 6-72 h of any tissue damaging event. Elevated blood levels correlate with the onset and extent of both activated inflammation and the acute phase biochemical response to the tissue insult. Because its functional bioactivity as the prototypic acute phase reactant has el

SUBMITTER: Rajab IM 

PROVIDER: S-EPMC7511658 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature