Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle.

ABSTRACT: Progress in shortening the duration of tuberculosis (TB) treatment is hampered by the lack of a predictive model that accurately reflects the diverse environment within the lung. This is important as TB has been shown to produce distinct localisations to different areas of the lung during different disease stages, with the environmental heterogeneity within the lung of factors such as air ventilation, blood perfusion and oxygen tension believed to contribute to the apical localisation witnessed during the post-primary form of the disease. Building upon our previous model of environmental lung heterogeneity, we present a networked metapopulation model that simulates TB across the whole lung, incorporating these notions of environmental heterogeneity across the whole TB life-cycle to show ho

SUBMITTER: Pitcher MJ 

PROVIDER: S-EPMC7511696 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature