Transcriptome Analysis of the Nematode Caenorhabditis elegans in Acidic Stress Environments.

ABSTRACT: Ocean acidification and acid rain, caused by modern industries' fossil fuel burning, lead to a decrease in the living environmental pH, which results in a series of negative effects on many organisms. However, the underlying mechanisms of animals' response to acidic pH stress are largely unknown. In this study, we used the nematode Caenorhabditis elegans as an animal model to explore the regulatory mechanisms of organisms' response to pH decline. Two major stress-responsive pathways were found through transcriptome analysis in acidic stress environments. First, when the pH dropped from 6.33 to 4.33, the worms responded to the pH stress by upregulation of the col, nas, and dpy genes, which are required for cuticle synthesis and structure integrity. Second, when t

SUBMITTER: Cong Y 

PROVIDER: S-EPMC7511720 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature