Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology.

ABSTRACT: Studying older adults with excellent cognitive capacities (Supernormals) provides a unique opportunity for identifying factors related to cognitive success - a critical topic across lifespan. There is a limited understanding of Supernormals' neural substrates, especially whether any of them attends shaping and supporting superior cognitive function or confer resistance to age-related neurodegeneration such as Alzheimer's disease (AD). Here, applying a state-of-the-art diffusion imaging processing pipeline and finite mixture modelling, we longitudinally examine the structural connectome of Supernormals. We find a unique structural connectome, containing the connections between frontal, cingulate, parietal, temporal, and subcortical regions in the same hemisphere that remains stable over tim

SUBMITTER: Chen Q 

PROVIDER: S-EPMC7511768 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature