High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI.

ABSTRACT:

Objectives

Successful neurosurgical intervention in gliomas depends on the precision of the preoperative definition of the tumor and its margins since a safe maximum resection translates into a better patient outcome. Metabolic high-resolution imaging might result in improved presurgical tumor characterization, and thus optimized glioma resection. To this end, we validated the performance of a fast high-resolution whole-brain 3D-magnetic resonance spectroscopic imaging (MRSI) method at 7T in a patient cohort of 23 high-grade gliomas (HGG).

Materials and methods

We preoperatively measured 23 patients with histologically verified HGGs (17 male, 8 female, age 53 ± 15) with an MRSI sequence based on concentric ring trajectories with a 64 × 64 × 39 measurement matrix, and a 3.4 ×

SUBMITTER: Hangel G 

PROVIDER: S-EPMC7511769 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature