Plasma proteomic profile of frailty.

ABSTRACT: Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes in aging, and is characterized by dysregulation across various biological pathways. Frailty may manifest biologically as alteration in protein expression, possibly regulated at genetic, transcriptional and epigenetic levels. In this study, we examined the proteomic profile associated with frailty defined by an established cumulative frailty index (FI). Using the SomaScan^® assay, 4265 proteins were measured in plasma, of which 55 were positively associated and 88 were negatively associated with the FI. The proteins most strongly associated with frailty were fatty acid-binding proteins, including fatty acid-binding protein (FABP) (p = 1.96 × 10^-19 ) and FABPA (p = 8.10 

SUBMITTER: Sathyan S 

PROVIDER: S-EPMC7511877 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature