Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

ABSTRACT:

Background

Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-state conditions or in the context of older age, when declines in insulin sensitivity and protein anabolism, as well as losses of muscle mass and function, occur.

Methods

Eight older-aged men (71 ± 1 year, mean ± SEM) were studied in a crossover trial. Baseline measures were taken over 3 hr, prior to a 3 hr postprandial insulin (~30 mIU ml^-1 ) and glucose (7-7.5 mM) clamp, alongside I.V. infusions of octreotide and Vamin 14 (±infusions of GLP-1). Four muscle biopsies were taken, and muscle protein turnover was quantified via incorporation of ¹³ C₆ phenylalanine and arteriovenous balance kine

SUBMITTER: Abdulla H 

PROVIDER: S-EPMC7511886 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature