Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.

ABSTRACT: Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosis and portal hypertension and in experimental mouse fibrosis. We found hepatic LCN2 expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with AH. In control human livers, LCN2 expressed exclusively in mononuclear cells, while its expression was markedly induced in AH livers, not only in mononuclear cells but also notably in hepatocytes. Lcn2^-/- mice were protected from liver fibrosis caused by either ethanol or CCl₄ exposure. Microarray analysis reveale

SUBMITTER: Chen J 

PROVIDER: S-EPMC7512007 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature