Integrated Analysis of Hub Genes and miRNAs in Dilated Cardiomyopathy.

ABSTRACT:

Purpose

The aim of this study is to identify hub genes and miRNAs by the miRNA-mRNA interaction network in dilated cardiomyopathy (DCM) disease.

Methods

The differentially expressed miRNAs (DEMis) and mRNAs (DEMs) were selected using data of DCM patients downloaded from the GEO database (GSE112556 and GSE3585). Gene Ontology (GO) pathway analysis and transcription factor enrichment analysis were used for selecting DEMis, and the target mRNAs of DEMis were filtered by using miRDB, miRTarBase, and TargetScan. Cytoscape software was used to visualize the network between miRNAs and mRNAs and calculate the hub genes. GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to analyze the mRNAs in the regulatory network.

Results

A total of 9 DEMis an

SUBMITTER: Huang K 

PROVIDER: S-EPMC7512046 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature