Role of SLC transporters in toxicity induced by anticancer drugs.

ABSTRACT:

Introduction

. Membrane transporters are integral to the maintenance of cellular integrity of all tissue and cell types. While transporters play an established role in the systemic pharmacokinetics of therapeutic drugs, tissue specific expression of uptake transporters can serve as an initiating mechanism that governs the accumulation and impact of cytotoxic drugs.

Areas covered

. This review provides an overview of organic cation transporters as determinants of chemotherapy-induced toxicities. We also provide insights into the recently updated FDA guidelines for in vitro drug interaction studies, with a particular focus on the class of tyrosine kinase inhibitors as perpetrators of transporter-mediated drug interactions.

Expert opinion

. Studies performed over

SUBMITTER: Huang KM 

PROVIDER: S-EPMC7512084 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature