Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: One-Year Results of the CANOA Randomized Clinical Trial.

ABSTRACT:

Importance

Adding clopidogrel to aspirin for 3 months after transcatheter atrial septal defect (ASD) closure results in a lower incidence of new-onset migraine attacks. However, the outcomes at 6- to 12-month follow-up (after clopidogrel cessation at 3 months) remain largely unknown.

Objective

To assess the incidence of migraine attacks at 6- and 12-month follow-up after transcatheter ASD closure.

Design, setting, and participants

This prespecified analysis of a randomized, double-blind clinical trial included patients with no prior history of migraine undergoing ASD closure from 6 university hospitals in Canada from December 2008 to November 2014. Patients were followed up at 3, 6, and 12 months, and a migraine headache questionnaire was administered at each time. An

SUBMITTER: Wintzer-Wehekind J 

PROVIDER: S-EPMC7512130 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature