Effects of changes on gut microbiota in children with acute Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) is an acute febrile illness of early childhood. The exact etiology of the disease remains unknown. At present, research on KD is mostly limited to susceptibility genes, infections, and immunity. However, research on the correlation between gut microbiota and KD is rare.

Methods

Children with a diagnosis of acute KD and children undergoing physical examination during the same period were included. At the time of admission, the subjects' peripheral venous blood and feces were collected. Faecal samples were analyzed for bacterial taxonomic content via high-throughput sequencing. The abundance, diversity, composition, and characteristic differences of the gut microbiota in KD and healthy children were compared by alpha diversity, beta diversity,

SUBMITTER: Shen J 

PROVIDER: S-EPMC7512135 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature