Genotoxic Effect of Salmonella Paratyphi A Infection on Human Primary Gallbladder Cells.

ABSTRACT: Carcinoma of the gallbladder (GBC) is the most frequent tumor of the biliary tract. Despite epidemiological studies showing a correlation between chronic infection with Salmonella enterica Typhi/Paratyphi A and GBC, the underlying molecular mechanisms of this fatal connection are still uncertain. The murine serovar Salmonella Typhimurium has been shown to promote transformation of genetically predisposed cells by driving mitogenic signaling. However, insights from this strain remain limited as it lacks the typhoid toxin produced by the human serovars Typhi and Paratyphi A. In particular, the CdtB subunit of the typhoid toxin directly induces DNA breaks in host cells, likely promoting transformation. To assess the underlying principles of transformation, we used gallbladder or

SUBMITTER: Sepe LP 

PROVIDER: S-EPMC7512552 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature