Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.

ABSTRACT: The interaction and communication between bacteria and their hosts modulate many aspects of animal physiology and behavior. Dauer entry as a response to chronic exposure to pathogenic bacteria in Caenorhabditis elegans is an example of a dramatic survival response. This response is dependent on the RNA interference (RNAi) machinery, suggesting the involvement of small RNAs (sRNAs) as effectors. Interestingly, dauer formation occurs after two generations of interaction with two unrelated moderately pathogenic bacteria. Therefore, we sought to discover the identity of C. elegans RNAs involved in pathogen-induced diapause. Using transcriptomics and differential expression analysis of coding and long and small noncoding RNAs, we found that mir-243-3p (the mature form of

SUBMITTER: Gabaldon C 

PROVIDER: S-EPMC7512553 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature