Cardiovascular risk factors from childhood and midlife physical function: The Bogalusa Heart Study.

ABSTRACT:

Objectives

Life-course models have been infrequently applied to physical function. We sought to examine the effects of the cumulative burden of cardiovascular risk factors (CVRFs) from childhood on physical function in midlife.

Methods

This longitudinal study consisted of 718 participants (aged 37 to 56 years at follow-up) who were examined for CVRFs at least four times during childhood and at least twice in adulthood, with 39 years of follow-up. We assessed physical function in 2013-2016 with the Short Physical Performance Battery (SPPB), 6-minute walking test (6MWT), and handgrip strength. The area under the growth curve (AUC) was used as a measure of cumulative exposure to CVRFs during childhood.

Results

AUC of HDL-cholesterol levels in childhood were positively as

SUBMITTER: Du T 

PROVIDER: S-EPMC7513196 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature