Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer's disease.

ABSTRACT:

Background

We aimed to investigate the clinical correlates of principal components (PCs) of tau positron emission tomography (PET) and their predictability for longitudinal changes in tau accumulation in Alzheimer's disease (AD).

Methods

We enrolled 272 participants who underwent two PET scans [¹⁸F-flortaucipir for tau and ¹⁸F-florbetaben for amyloid-β (Aβ)], brain magnetic resonance imaging, and neuropsychological tests as baseline assessments. Among them, 187 participants underwent the same follow-up assessments after an average of 2 years. Using Aβ-positive AD dementia-specific PCs obtained from the baseline scans of 56 Aβ-positive patients with AD dementia, we determined the expression of the first two PCs (PC1 and PC2) in all participants. We asses

SUBMITTER: Cho H 

PROVIDER: S-EPMC7513482 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature