Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies.

ABSTRACT:

Background

Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels. Based on inherited complement defects, patients with transiently low complement may be at similar risk for serious bacterial infection, but the degree of risk related to C3 level and temporal association is unknown.

Methods

We performed a retrospective study including pediatric patients with undetectable total complement activity or absent individual complement components measured at our institution from 2002 to 2018. We assessed annual rate of serious bacterial infection (SBI) defined as requiring hospitalization and/or parenteral antibiotics by manual chart review. Among included SLE

SUBMITTER: Al-Shaikhly T 

PROVIDER: S-EPMC7513499 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature