Adding exogenous biglycan or decorin improves tendon formation for equine peritenon and tendon proper cells in vitro.

ABSTRACT:

Background

Tendon injuries amount to one of the leading causes of career-ending injuries in horses due to the inability for tendon to completely repair and the high reinjury potential. As a result, novel therapeutics are necessary to improve repair with the goal of decreasing leg lameness and potential reinjury. Small leucine-rich repeat proteoglycans (SLRPs), a class of regulatory molecules responsible for collagen organization and maturation, may be one such therapeutic to improve tendon repair. Before SLRP supplementation can occur in vivo, proper evaluation of the effect of these molecules in vitro needs to be assessed. The objective of this study was to evaluate the effectiveness of purified bovine biglycan or decorin on tendon proper and peritenon cell populations in three-di

SUBMITTER: Pechanec MY 

PROVIDER: S-EPMC7513506 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature