Lung function, pharmacokinetics, and tolerability of inhaled indacaterol maleate and acetate in asthma patients.

ABSTRACT:

Background

Indacaterol maleate delivered with the Breezhaler® inhalation device is a long-acting β₂-agonist approved for chronic obstructive pulmonary disease. In the development of a once daily, inhaled fixed dose combination (FDC) of indacaterol, glycopyrronium bromide (a long-acting muscarinic antagonist), and mometasone furoate (an inhaled corticosteroid [ICS]) for the treatment of patients with asthma, the acetate salt of indacaterol is used instead of the maleate salt. Here, we investigated the lung function, pharmacokinetics (PK) and safety of indacaterol maleate 150 μg once daily (o.d.) and indacaterol acetate 150 μg o.d. in comparison with placebo.

Methods

This was a randomised, double-blind, three-period crossover study (ClinicalTrials.gov identifier, NC

SUBMITTER: Miller D 

PROVIDER: S-EPMC7513528 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature