Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid.

ABSTRACT:

Objective

To determine the effect of 9-cis retinoic acid (9-cis RA) on postsurgical lymphedema.

Background

9-cis RA promotes lymphangiogenesis in vitro and in vivo and has promise as a therapeutic agent to limit the development of postsurgical lymphedema.

Methods

Lymphedema was induced in the right hind limb after a single fraction of 20 Gy radiation, popliteal lymphadenectomy, and lymphatic vessel ablation. Postoperatively, mice were randomly divided in to 2 groups that received daily intraperitoneal injections of either (1) an oil-based vehicle solution (control) or (2) 0.08 mg/kg of 9-cis RA dissolved in a vehicle solution. Outcome measures included paw thickness, lymphatic drainage, and lymphatic vessel density as measured by podoplanin immunohistochemistry and wh

SUBMITTER: Bramos A 

PROVIDER: S-EPMC7513676 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature