The Phenotypic Consequences of Genetic Divergence between Admixed Latin American Populations: Antioquia and Choco, Colombia.

ABSTRACT: Genome-wide association studies have uncovered thousands of genetic variants that are associated with a wide variety of human traits. Knowledge of how trait-associated variants are distributed within and between populations can provide insight into the genetic basis of group-specific phenotypic differences, particularly for health-related traits. We analyzed the genetic divergence levels for 1) individual trait-associated variants and 2) collections of variants that function together to encode polygenic traits, between two neighboring populations in Colombia that have distinct demographic profiles: Antioquia (Mestizo) and Chocó (Afro-Colombian). Genetic ancestry analysis showed 62% European, 32% Native American, and 6% African ancestry for Antioquia compared with 76% African, 10% European,

SUBMITTER: Chande AT 

PROVIDER: S-EPMC7513793 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature