Male breast cancer: a disease distinct from female breast cancer.

ABSTRACT:

Purpose

Male breast cancer (BC) is rare, representing approximately 1% of cancers that occur in men and approximately 1% of all BCs worldwide. Because male BC is rare, not much is known about the disease, and treatment recommendations are typically extrapolated from data available from clinical trials enrolling female BC patients.

Methods

We review the epidemiology, risk factors, prognosis, and the varied molecular and clinicopathologic features that characterize male BC. In addition, we summarize the available data for the use of systemic therapy in the treatment of male BC and explore the ongoing development of targeted therapeutic agents for the treatment of this subgroup of BCs.

Results

There are important biological differences between male and female BC. Male BC

SUBMITTER: Gucalp A 

PROVIDER: S-EPMC7513797 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature