Early childhood general anesthesia exposure associated with later developmental delay: A national population-based cohort study.

ABSTRACT: Exposure to general anesthesia has been reported to induce neurotoxicity, impair learning, memory, attention, motor functions, as well as affect behavior in adult rodents and nonhuman primates. Though many have speculated similar effects in humans, previous literature has shown conflicting findings. To investigate the differences in risk of developmental delay among young children exposed to general anesthesia compared to matched unexposed individuals, a population-based cohort study was conducted with a longitudinal dataset spanning 2000 to 2013 from the Taiwan National Health Insurance Research Database (NHIRD). Procedure codes were used to identify children who received anesthesia. For each exposed child, two unexposed children matched by gender and age were enrolled into the comparison

SUBMITTER: Feng YP 

PROVIDER: S-EPMC7513996 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature