A Suggestion of Converting Protein Intrinsic Disorder to Structural Entropy Using Shannon's Information Theory.

ABSTRACT: We propose a framework to convert the protein intrinsic disorder content to structural entropy (H) using Shannon's information theory (IT). The structural capacity (C), which is the sum of H and structural information (I), is equal to the amino acid sequence length of the protein. The structural entropy of the residues expands a continuous spectrum, ranging from 0 (fully ordered) to 1 (fully disordered), consistent with Shannon's IT, which scores the fully-determined state 0 and the fully-uncertain state 1. The intrinsically disordered proteins (IDPs) in a living cell may participate in maintaining the high-energy-low-entropy state. In addition, under this framework, the biological functions performed by proteins and associated with the order or disorder of thei

SUBMITTER: Guo HB 

PROVIDER: S-EPMC7515080 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature