Sequence Versus Composition: What Prescribes IDP Biophysical Properties?

ABSTRACT: Intrinsically disordered proteins (IDPs) represent a distinct class of proteins and are distinguished from globular proteins by conformational plasticity, high evolvability and a broad functional repertoire. Some of their properties are reminiscent of early proteins, but their abundance in eukaryotes, functional properties and compositional bias suggest that IDPs appeared at later evolutionary stages. The spectrum of IDP properties and their determinants are still not well defined. This study compares rudimentary physicochemical properties of IDPs and globular proteins using bioinformatic analysis on the level of their native sequences and random sequence permutations, addressing the contributions of composition versus sequence as determinants of the properties. IDPs have, on average, lowe

SUBMITTER: Vymetal J 

PROVIDER: S-EPMC7515148 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature