Cohesion of Sister Chromosome Termini during the Early Stages of Sporulation in Bacillus subtilis.

ABSTRACT: During sporulation of Bacillus subtilis, the cell cycle is reorganized to generate separated prespore and mother cell compartments, each containing a single fully replicated chromosome. The process begins with reorganization of the nucleoid to form an elongated structure, the axial filament, in which the two chromosome origins are attached to opposite cell poles, with the remainder of the DNA stretched between these sites. When the cell then divides asymmetrically, the division septum closes around the chromosome destined for the smaller prespore, trapping the origin-proximal third of the chromosome in the prespore. A translocation pore is assembled through which a DNA transporter, SpoIIIE/FtsK, transfers the bulk of the chromosome to complete the segregation process. Although the mechanis

SUBMITTER: Willis C 

PROVIDER: S-EPMC7515245 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature