Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications.

ABSTRACT: Transitions between enzyme functional states are often connected to conformational changes involving electron or proton transport and directional movements of a group of atoms. These microscopic fluxes, resulting in entropy production, are driven by non-equilibrium concentrations of substrates and products. Maximal entropy production exists for any chosen transition, but such a maximal transitional entropy production (MTEP) requirement does not ensure an increase of total entropy production, nor an increase in catalytic performance. We examine when total entropy production increases, together with an increase in the performance of an enzyme or bioenergetic system. The applications of the MTEP theorem for transitions between functional states are described for the triosephosphate isomerase,

SUBMITTER: Juretic D 

PROVIDER: S-EPMC7515272 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature