Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer.

ABSTRACT: Ubiquitin-specific proteases (USPs) play important roles in the regulation of many cancer-related biological processes. USPs copy number variation (CNVs) may affect the risk and prognosis of colorectal cancer (CRC). We detected CNVs of USPs genes in 468 matched CRC patients and controls, estimated the associations between the USPs genes CNVs and CRC risk and prognosis and their interactions with environmental factors on CRC risk. Finally, we generated five CRC risk predictive models with different CNVs patterns combining with environmental factors (EF). We identified significant association between CYLD deletion and CRC risk (OR_adj = 4.18, 95% CI: 2.03-8.62), significant association between USP9X amplification and CRC risk (OR_adj = 2.30, 95% CI: 1.48-3.57), and signif

SUBMITTER: Tian T 

PROVIDER: S-EPMC7515516 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature