STAT4-mediated down-regulation of miR-3619-5p facilitates stomach adenocarcinoma by modulating TBC1D10B.

ABSTRACT:

Background

MicroRNAs (miRNAs) as the subtype of non-coding RNAs are revealed to be crucial players in cellular activities. It has been reported that miR-3619-5p functions as a tumor inhibitor in several cancers. However, the connection between miR-3619-5p and stomach adenocarcinoma (STAD) remains to be discovered.

Aim of the study

The purpose of the study is to figure out the role and molecular regulation mechanism of miR-3619-5p in STAD.

Methods

The expression of miR-3619-5p was evaluated via qRT-PCR analysis. Gain-of-function experiments demonstrated the effects of miR-3619-5p on cellular functions. The upper-stream transcription factor STAT4 and downstream target gene TBC1D10B of miR-3619-5p were identified by bioinformatic analysis. The binding and interaction bet

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7515538 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature