Ontology highlight
ABSTRACT:
SUBMITTER: Codding SJ
PROVIDER: S-EPMC7515569 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Codding Sara J SJ Johnson Ashley A AA Trudeau Matthew C MC
Channels (Austin, Tex.) 20201201 1
The KCNH family comprises the ERG, EAG, and ELK voltage-activated, potassium-selective channels. Distinct from other K channels, KCNH channels contain unique structural domains, including a PAS (Per-Arnt-Sim) domain in the N-terminal region and a CNBHD (cyclic nucleotide-binding homology domain) in the C-terminal region. The intracellular PAS domains and CNBHDs interact directly and regulate some of the characteristic gating properties of each type of KCNH channel. The PAS-CNBHD interaction regu ...[more]