Ontology highlight
ABSTRACT:
SUBMITTER: Summer S
PROVIDER: S-EPMC7515705 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20200901 17
Ribosome biogenesis requires numerous trans-acting factors, some of which are deeply conserved. In Bacteria, the endoribonuclease YbeY is believed to be involved in 16S rRNA 3'-end processing and its loss was associated with ribosomal abnormalities. In Eukarya, YBEY appears to generally localize to mitochondria (or chloroplasts). Here we show that the deletion of human YBEY results in a severe respiratory deficiency and morphologically abnormal mitochondria as an apparent consequence of impaired ...[more]