Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease.

ABSTRACT: BACKGROUND AND OBJECTIVES:Associations between blood lipids and risk of ischemic heart disease (IHD) have been reported in observational studies. However, due to confounding and reverse causation, observational studies are influenced by bias, thus their results show inconsistency in the effects of lipid levels on IHD. In this study, we evaluate whether lipid levels have an effect on the risk of IHD in a Korean population. METHODS:A 2-sample Mendelian randomization (MR) study, using the genetic variants associated with lipid levels as the instrumental variables was performed. Genetic variants significantly associated with lipid concentrations were obtained from the Korean Genome and Epidemiology Study (n=35,000), and the same variants on IHD were obtained from the Korean Cancer Prevention S

SUBMITTER: Lee SH 

PROVIDER: S-EPMC7515757 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature