¹⁸F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases.

ABSTRACT: ¹⁸F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[¹⁸F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo that binds to Aβ with excellent affinity (K_d 0.7 ± 0.2) and high selectivity over tau and α-synuclein aggregates (Ki > 1000 nM). We aimed to characterize ¹⁸F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to the reference compound PiB. Six patients (mild late-onset and moderate early-onset AD dementia, mild cognitive impairment due to AD, intermediate likelihood, mild behavioral variant of frontotemporal dementia, subjective memory impairment without evidence

SUBMITTER: Grimmer T 

PROVIDER: S-EPMC7515824 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature