Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.

ABSTRACT: Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10^-8) and rs6880461 (p-value: 9.5 × 10^-8

SUBMITTER: Erlangsen A 

PROVIDER: S-EPMC7515833 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature